International Conference on Systems Biology in 2018 was held in 27. October - 1.November in Lyon, France. The conference venue was located in a couple of hundred meters from the International Criminal Police Organization (INTERPOL) headquarters and we all could feel safe. The conference was announced already at ICSB 2017 in Virginia and we could observe the truly well-organised event. The institute was represented by Agris Pentjuss and Egils Stalidzans who participated in a number of tutorials (including COPASI, of course) and sessions.